In the treatment of hereditary angioedema (HAE)
WHAT IF YOU COULD
WITHOUT DEFLATING EXPECTATIONS?
In the treatment of hereditary angioedema (HAE)
WHAT IF YOU COULD
WITHOUT DEFLATING EXPECTATIONS?
In the treatment of hereditary angioedema (HAE)
WHAT IF YOU COULD
WITHOUT DEFLATING EXPECTATIONS?
Life with HAE can be a burden.
The treatment shouldn’t be.1,2
Not a person
with HAE.
In the treatment of hereditary angioedema (HAE)
WHAT IF YOU COULD
WITHOUT DEFLATING EXPECTATIONS?
Life with HAE can be a burden.
The treatment shouldn’t be.1,2
In the treatment of hereditary angioedema (HAE)
WHAT IF YOU COULD
WITHOUT DEFLATING EXPECTATIONS?
Life with HAE can be a burden.
The treatment shouldn’t be.1,2
In the treatment of hereditary angioedema (HAE)
WHAT IF YOU COULD
WITHOUT DEFLATING EXPECTATIONS?
Life with HAE can be a burden.
The treatment shouldn’t be.1,2
Not a person with HAE.
In the treatment of
hereditary angioedema (HAE)
WHAT IF YOU COULD
WITHOUT DEFLATING EXPECTATIONS?
Life with HAE can be a burden.
The treatment shouldn’t be.1,2
In the treatment of
hereditary angioedema (HAE)
WHAT IF YOU COULD
WITHOUT DEFLATING EXPECTATIONS?
Life with HAE can be a burden.
The treatment shouldn’t be.1,2
In the treatment of
hereditary angioedema (HAE)
WHAT IF YOU COULD
WITHOUT DEFLATING EXPECTATIONS?
Life with HAE can be a burden.
The treatment shouldn’t be.1,2
Not a person
with HAE.
While current HAE treatment has reduced the disease burden, people may be making trade-offs among efficacy, tolerability, and convenience.1-3
HAE Facts
In a 2007 survey with members of the U.S. Hereditary Angioedema Association (HAEA), people with HAE have ~27 swelling attacks per year on average1
According to a 2011 European study with 186 people with HAE, people with HAE and their caregivers miss an average of 20 days of work or school per year1,4
Estimates state people with HAE lose between 20 to 100 days of social activities annually5
HAE attacks are often disfiguring and debilitating, imposing a significant burden on people’s quality of life1
Attacks that affect the throat can cause swelling, trouble breathing, and the chance for suffocation if not treated6-8
Not a person
with HAE.
HAE Overview
HAE is rare, unpredictable,
and potentially life-threatening.1,9
Subscribe to learn more
Learn more about the trade-offs people with HAE may have to make. Sign up for periodic updates.
References
1. Lumry WR, et al. Allergy Asthma Proc. 2020;41(Suppl 1):S08-S13. 2. Betschel SD, et al. J Allergy Clin Immunol Pract. 2023;11(8):2315-2325. 3. Radojicic C, et al. Allergy Asthma Proc. 2021;42(3):S4-S10. 4. Aygören-Pürsün E, et al. Orphanet J Rare Dis. 2014;9(99):1-9. 5. Savarese L, et al. Allergy Asthma Proc. 2021;42(1):e1-e7. 6. Maurer M, et al. Allergy. 2022;77(7):1961-1990. 7. National Organization for Rare Disorders. Hereditary angioedema. https://rarediseases.org/rare-diseases/hereditary-angioedema/. Accessed January 3, 2024. 8. Santos GM, et al. Cureus. 2023;15(10):e47644. 9. Christiansen SC, et al. Ann Allergy Asthma Immunol. 2023;131(6):766-774.e8. 10. Food and Drug Administration. The voice of the patient - Hereditary angioedema. Published May 2018. https://www.fda.gov/files/about%20fda/published/The-Voice-of-the-Patient---Hereditary-Angioedema.pdf. Accessed February 14, 2024. 11. Longhurst HJ, et al. Br J Hosp Med (Lond). 2019;80(7):391-398. 12. Gülbahar O. Balkan Med J. 2021;38(2):73-81. 13. Bork K, et al. Allergy Asthma Clin Immunol. 2021;17(1):40. 14. Manning ME. Allergy Asthma Proc. 2020;41(Suppl 1):S22-S25. 15. Farkas H, et al. Clin Transl Allergy. 2021;11(4):e12035. 16. Zuraw BL. World Allergy Organ J. 2010;3(9 Suppl):S25-S28. 17. Aygören-Pürsün E, et al. Allergy. 2013;68(8):1034-1039. 18. Fouche AS, et al. Ann Allergy Asthma Immunol. 2014;112(4):371-375. 19. Lo SH, et al. Pharmacoecon Open. 2022;6(2):231-239. 20. Anderson J, et al. Allergy Asthma Clin Immunol. 2021;17(1):60. 21. Chong-Neto HJ. World Allergy Organ J. 2023;16(3):100758. 22. Riedl MA, et al. Allergy Asthma Proc. 2021;42(3):S17-S25. 23. Soteres DF, et al. Clin Case Rep. 2021;9(11):e05086. 24. Riedl MA, et al. Ann Allergy Asthma Immunol. 2017;119(1):59-64. 25. Covella B, et al. Future Pharmacology. 2024;4(1):41-53. 26. Wedner HJ, et al. J Allergy Clin Immunol Pract. 2021;9(6):2305-2314.e4. 27. Riedl MA, et al. Allergy. 2020;75(11):2879-2887. 28. Busse PJ, et al. J Allergy Clin Immunol Pract. 2021;9(1):132-150.e3. 29. Geba D, et al. J Drug Assess. 2021;10(1):51-56. 30. Mayo Clinic. Berotralstat (oral route). https://www.mayoclinic.org/drugs-supplements/berotralstat-oral-route/side-effects/drg-20506380?p=1. Accessed January 17, 2024. 31. Abdulkarim A, et al. Hereditary angioedema. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482266/ 32. Angioedema Centers of Reference and Excellence. Who we are. https://acare-network.com. Accessed January 16, 2024. 33. US Hereditary Angioedema Association. https://www.haea.org/. Accessed January 16, 2024. 34. Hereditary Angioedema International. About HAEi. https://haei.org/about-haei/. Accessed January 16, 2024. 35. Everyday Health. Speaking hereditary angioedema (HAE): a glossary of terms used to describe symptoms, tests, treatments, and more. https://www.everydayhealth.com/hereditary-angioedema/glossary-of-terms-used-to-describe-symptoms-tests-treatments-and-more/. Accessed January 16, 2024. 36. Allergy & Immunology Medical Center. Glossary of Allergy Terms. https://www.aimedcenter.com/patient-information/patient-education/glossary-of-terms/. Accessed January 19, 2024. 37. Healthline. What is a hematologist? https://www.healthline.com/health/what-is-a-hematologist. Accessed January 17, 2024. 38. Purdue University. College of Science. Career development. https://www.purdue.edu/science/careers/what_can_i_do_with_a_major/Career%20Pages/immunologist.html#:~:text=Immunologists%20are%20research%20scientist. Accessed January 17, 2024.